siRNA screen identifies QPCT as a druggable target for Huntington's disease.

doi:10.1038/nchembio.1790

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Article

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Nature chemical biology - 1 May 2015

Jimenez-Sanchez Maria, Lam Wun, Hannus Michael, Sönnichsen Birte, Imarisio Sara, Fleming Angeleen, Tarditi Alessia, Menzies Fiona, Dami Teresa Ed, Xu Catherine, Gonzalez-Couto Eduardo, Lazzeroni Giulia, Heitz Freddy, Diamanti Daniela, Massai Luisa, Satagopam Venkata P, Marconi Guido, Caramelli Chiara, Nencini Arianna, Andreini Matteo, Sardone Gian Luca, Caradonna Nicola P, Porcari Valentina, Scali Carla, Schneider Reinhard, Pollio Giuseppe, O'Kane Cahir J, Caricasole Andrea, Rubinsztein David C

Abstract excerpt

Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a large-scale 'druggable genome' siRNA screen in human cultured cells, followed...

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Identifiers

PMID: 25848931
DOI: 10.1038/nchembio.1790
PMCID: PMC4696152

Genes

HTT
QPCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25848931-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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