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Article

Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2009

Kure Shoko, Nosho Katsuhiko, Baba Yoshifumi, Irahara Natsumi, Shima Kaori, Ng Kimmie, Meyerhardt Jeffrey A, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Vitamin D is associated with decreased risks of various cancers, including colon cancer. The vitamin D receptor (VDR) is a transcription factor, which plays an important role in cellular differentiation and inhibition of proliferation. A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has been suggested. However, the prognostic role of VDR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19789368
DOI: 10.1158/1055-9965.EPI-09-0490
PMCID: PMC2768137

Genes

VDR
KRAS
BRAF
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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