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Article

Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans.

PloS one - 1 Jan 2011

Ashktorab Hassan, Nguza Bijou, Fatemi Mehrnaz, Nouraie Mehdi, Smoot Duane T, Schäffer Alejandro A, Kupfer Sonia S, Camargo Carlos A, Brim Hassan

Abstract excerpt

BACKGROUND: There are sparse data on genetic, epigenetic and vitamin D exposure in African Americans (AA) with colon polyp. Consequently, we evaluated serum 25(OH) D levels, vitamin D receptor (VDR) polymorphisms and the methylation status of the tumor suppressor gene dickkopf homolog 1 (DKK1) as risk factors for colon polyp in this population. METHODS: The case-control study consisted of 93 patients with colon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22022386
DOI: 10.1371/journal.pone.0025314
PMCID: PMC3192764

Genes

DKK1
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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