Article
Molecular characterisation of C4 null alleles found in Felty's syndrome.
Annals of the rheumatic diseases - 1 Oct 1990
Hillarby M C, Strachan T, Grennan D M
Abstract excerpt
A higher prevalence of C4B null alleles is found in Felty's syndrome. The molecular basis of C4 null alleles was investigated by studying restriction fragment length polymorphisms (RFLPs) obtained with C4 and 21-hydroxylase (21-OH) DNA probes and by pulsed field gel electrophoresis in 30 subjects with Felty's syndrome. C4A null alleles were found in 10 subjects, and in five of these were associated with a...
Topics
- Alleles
- Chromosome Deletion
- Complement C4
- Complement C4a
- Felty Syndrome
- Humans
- Nucleic Acid Hybridization
- Pedigree
- Polymorphism, Restriction Fragment Length
- Steroid 21-Hydroxylase