Article
Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene-induced genotoxicity in vivo.
Environmental and molecular mutagenesis - 1 Dec 2017
Masumura Kenichi, Toyoda-Hokaiwado Naomi, Niimi Naoko, Grúz Petr, Wada Naoko A, Takeiri Akira, Jishage Kou-Ichi, Mishima Masayuki, Nohmi Takehiko
Abstract excerpt
DNA polymerase kappa (Polk) is a specialized DNA polymerase involved in translesion DNA synthesis. To understand the protective roles against genotoxins in vivo, we established inactivated Polk knock-in gpt delta (inactivated Polk KI) mice that possessed reporter genes for mutations and expressed inactive Polk. In this study, we examined genotoxicity of benzo[a]pyrene (BP) to determine whether Polk actually...
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