Article
+49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population.
Human immunology - 1 Jan 2010
Gu Xing, Qi Peng, Zhou Feiguo, Ji Qiang, Wang Hao, Dou Tonghai, Zhao Yunpeng, Gao Chunfang
Abstract excerpt
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important regulator and functions negatively in immune response. Its nonsynonymous polymorphism +49G > A (dbSNP: rs231775) has been linked to an elevated risk of T-cell-mediated autoimmune diseases, infectious diseases, and even carcinomas. Here, we examined the genotypes at rs231775 of 1003 subjects in a Han Chinese population to detect the association between this...
Topics
- Adult
- Alleles
- Antigens, CD
- Asian People
- CTLA-4 Antigen
- Carcinoma, Hepatocellular