Article
Influence of cytotoxic T lymphocyte-associated antigen 4 polymorphisms on the outcomes of hepatitis B virus infection.
Molecular medicine reports - 1 Feb 2014
Chen Man, Chang Ying, Tang Feng, Xie Qiong-Hui, Li Jin, Yang Hong, He Xing-Xing, Lin Ju-Sheng
Abstract excerpt
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-control study was conducted. A total of 1,119 unrelated individuals were recruited. The CTLA-4 variants...
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