Article
CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.
Human immunology - 1 Sept 2010
Hu Lingmin, Liu Jibin, Chen Xiaojun, Zhang Yixin, Liu Li, Zhu Jian, Chen Jianguo, Shen Hongbing, Qiang Fulin, Hu Zhibin
Abstract excerpt
Accumulated evidence suggested that cytotoxic T-lymphocyte antigen 4 (CTLA4) plays an important role in the negative regulation of T-cell proliferation and activation, and thus participates in antitumor immunity and cancer surveillance. Previously we reported that the CTLA4 49A/G (rs231775) single nucleotide polymorphism (SNP) was a candidate cancer susceptibility marker for breast, lung, esophageal, and gastric...
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