Article
[Pituitary adenoma: mechanisms of endocrine oncogenesis].
La Revue du praticien - 15 Jun 1996
Bertherat J, Bertagna X
Abstract excerpt
Molecular studies on pituitary adenomas support a major role of molecular alterations in the pathogenesis of pituitary adenomas. Nevertheless, alterations in the neuro-hormonal control of the pituitary could also be involved in pituitary tumors formation. The finding that most pituitary adenomas are monoclonal has stimulated a search for somatic mutations. For instance, activating mutations of the Gs protein,...
Topics
- Adenoma
- Animals
- Cell Differentiation
- Female
- Genes
- Genes, Tumor Suppressor
- Growth Substances
- Humans
- Hypothalamic Hormones
- Male
- Mice
- Mutation
- Oncogenes
- Pituitary Neoplasms
- Pregnancy