Article
Ultrastructural alterations in plasma membranes from drug-resistant P388 murine leukemia cells.
Biochimica et biophysica acta - 2 Nov 1990
García-Segura L M, Ferragut J A, Ferrer-Montiel A V, Escriba P V, Gonzalez-Ros J M
Abstract excerpt
Freeze-fracture studies of daunomycin-sensitive and daunomycin-resistant P388 cell lines, reveal a significant increase in the numerical density of intramembrane particles at both, the protoplasmic and the exoplasmic leaflets of the plasma membrane from the drug-resistant cells. Such change in pl...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Membrane
- Daunorubicin
- Drug Resistance
- Exocytosis
- Freeze Fracturing
- Leukemia P388
- Membrane Glycoproteins
- Mice
- Phenotype
- Tumor Cells, Cultured