Article
Phenotypic variations dictate the intracellular compartmentalization of doxorubicin in normal human bone marrow cells.
Cancer chemotherapy and pharmacology - 1 Jan 1990
Aghaï E, Tökés Z A
Abstract excerpt
In vitro accumulation of doxorubicin in intracellular compartments of normal bone marrow cells was studied with the use of fluorescent microscopy. Both the cytoplasmic and nuclear compartments had distinguishable drug accessibility in the diverse hemopoietic series and in different stages of maturation of each lineage. Nuclei appeared to be more sheltered in the myelogranulocytic series than in the nucleated...
Topics
- Bone Marrow
- Cell Compartmentation
- Cell Nucleus
- Chromatin
- Cytoplasm
- Doxorubicin
- Drug Resistance
- Granulocytes
- Humans
- In Vitro Techniques
- Macrophages
- Microscopy, Fluorescence