Article
Next generation sequencing of BRCA genes in glioblastoma multiform Egyptian patients: a pilot study.
Archives of physiology and biochemistry - 1 Jun 2022
Nageeb Amira M, Mohamed Magdy M, Ezz El Arab Lobna R, Khalifa Mohamed K, Swellam Menha
Abstract excerpt
BACKGROUND: Germ line mutations of BRCA1 and BRCA2 were correlated with a variety of cancer Authors aimed to use next-generation sequencing (NGS) to detect BRCA1 and BRCA2 germ line mutations in glioblastoma multiform (GBM) Egyptian patients. MATERIALS AND METHODS: Genomic DNA was extracted from six GBM cases, amplified using Ion AmpliSeq BRCA1 and BRCA2 panel. DNA libraries were pooled, barcoded and finally...
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