Article
Combining metaphase cytogenetics with single nucleotide polymorphism arrays can improve the diagnostic yield and identify prognosis more precisely in myelodysplastic syndromes.
Annals of medicine - 1 Dec 2022
Qin Yao, Zhang Hang, Feng Lin, Wei Haichen, Wu Yuling, Jiang Chaoran, Xu Zhihong, Zhu Huanling, Liu Ting
Abstract excerpt
BACKGROUND: Myelodysplastic syndromes (MDS) encompass a group of heterogeneous haematopoietic stem cell malignancies characterised by ineffective haematopoiesis, cytological aberrations, and a propensity for progression to acute myeloid leukaemia. Diagnosis and disease prognostic stratification are much based on genomic abnormalities. The traditional metaphase cytogenetics analysis (MC) can detect about 40-60%...
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