Article
Detection of cryptic chromosomal lesions including acquired segmental uniparental disomy in advanced and low-risk myelodysplastic syndromes.
Experimental hematology - 1 Nov 2007
Gondek Lukasz P, Haddad Abdo S, O'Keefe Christine L, Tiu Ramon, Wlodarski Marcin W, Sekeres Mikkael A, Theil Karl S, Maciejewski Jaroslaw P
Abstract excerpt
OBJECTIVES: Using metaphase cytogenetics (MC), chromosomal defects can be detected in 40% to 60% of patients with myelodysplastic syndromes (MDS); cytogenetic results have a major impact on prognosis. We hypothesize that more precise methods of chromosomal analysis will detect new/additional cryptic lesions in a higher proportion of MDS patients. METHODS: We have applied single nucleotide polymorphism microarrays...
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