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Article

Allosteric control of regulated scaffolding in membrane-associated guanylate kinases.

Biochemistry - 27 Oct 2009

Marcette Jana, Hood Iris V, Johnston Christopher A, Doe Chris Q, Prehoda Kenneth E

Abstract excerpt

Membrane-associated guanylate kinases (MAGUKs) organize protein complexes at specific cellular sites by regulating interactions with their COOH-terminal guanylate kinase-like domains (GKs). Negative regulation of MAGUK GKs by an adjacent Src homology 3 domain (SH3) is critical for function, yet the mechanism is poorly understood. To gain insight into this process, we investigated SH3 regulation of the Discs large...

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Identifiers

PMID: 19769408
DOI: 10.1021/bi901160f
PMCID: PMC3535437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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