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Article

Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011

Johnston Christopher A, Whitney Dustin S, Volkman Brian F, Doe Chris Q, Prehoda Kenneth E

Abstract excerpt

New protein functions can require complex sequence changes, but the minimal path is not well understood. The guanylate kinase enzyme (GK(enz)), which catalyzes phosphotransfer from ATP to GMP, evolved into the GK domain (GK(dom)), a protein-binding domain found in membrane associate guanylate kinases that function in mitotic spindle orientation and cell adhesion. Using an induced polarity assay for GK(dom)...

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Identifiers

PMID: 21990344
DOI: 10.1073/pnas.1104365108
PMCID: PMC3207680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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