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Article

Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases.

The Journal of biological chemistry - 28 Feb 2003

Olsen Olav, Bredt David S

Abstract excerpt

Membrane-associated guanylate kinases (MAGUKs) regulate cellular adhesion and signal transduction at sites of cell-cell contact. MAGUKs are composed of modular protein-protein interaction motifs including L27, PDZ, Src homology (SH) 3, and guanylate kinase domains that aggregate adhesion molecules and receptors. Genetic analyses reveal that lethal mutations of MAGUKs often occur in the guanylate kinase domain,...

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Source

Identifiers

PMID: 12482754
DOI: 10.1074/jbc.M210165200

Genes

PSD
CASK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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