miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT

Abstract excerpt

Abstract Background Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis. Methods miRNA microarray analysis and real-time PCR were used to determine the miRNA expression profiles in a cohort of 69 clinical samples including 50 CD117 IHC+ /KIT mutation GISTs and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gastrointestinal disorders and treatments
• Share to Gastrointestinal Tumor Research and Treatment
• Share to Teratomas and Epidermoid Cysts