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Article

Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs.

Behavioural brain research - 20 Jan 2010

Espallergues Julie, Galvan Laurie, Sabatier Florence, Rana-Poussine Vanessa, Maurice Tangui, Chatonnet Arnaud

Abstract excerpt

Decrease in the expression or activity of acetylcholinesterase (AChE) enzymatic activity results in increased cholinergic tonus in the brain and periphery, with concomitant regulations of nicotinic and muscarinic receptors expression. We generated AChE knockout mice and characterized the behavioral phenotype of heterozygous animals, focusing on learning and memory functions. Male and female, AChE+/- and AChE+/+...

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Identifiers

PMID: 19766675
DOI: 10.1016/j.bbr.2009.09.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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