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Article

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

Current Alzheimer research - 1 Jul 2005

Rees Tina M, Berson Amit, Sklan Ella H, Younkin Linda, Younkin Steven, Brimijoin Stephen, Soreq Hermona

Abstract excerpt

Current mouse models of Alzheimer's disease show brain pathology that correlates to a degree with memory impairment, but underlying molecular mechanisms remained unknown. Here we report studies with three lines of transgenic mice: animals that doubly express mutated human amyloid precursor protein (APPswe) and human acetylcholinesterase (hAChE); and animals transgenic for only the APPswe or the hAChE. Among these...

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PMID: 15974894
DOI: 10.2174/1567205054367847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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