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Article

Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice.

Neuroscience - 1 Jan 2004

Hartmann J, Erb C, Ebert U, Baumann K H, Popp A, König G, Klein J

Abstract excerpt

Alzheimer's disease is characterized by amyloid peptide formation and deposition, neurofibrillary tangles, central cholinergic dysfunction, and dementia; however, the relationship between these parameters is not well understood. We studied the effect of amyloid peptide formation and deposition on central cholinergic function in knock-in mice carrying the human amyloid precursor protein (APP) gene with the...

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Source

Identifiers

PMID: 15120860
DOI: 10.1016/j.neuroscience.2004.02.038

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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