Article
Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study.
Neuroscience letters - 20 Nov 2009
Ahn Kyungsook, Song Ju Hee, Kim Doh Kwan, Park Moon Ho, Jo Sangmee A, Koh Young Ho
Abstract excerpt
Ubiquitin-conjugating enzyme E2I (Ubc9) ligates small ubiquitin-related modifier (SUMO) to target proteins, resulting in changes of their localization, activity, or stability. Sumoylation of amyloid precursor protein (APP) was reported to be associated with decreased levels of beta amyloid (Abeta...
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