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Article

Polymorphisms of small ubiquitin-related modifier genes are associated with risk of Alzheimer's disease in Korean: A case-control study.

Journal of the neurological sciences - 15 May 2016

Mun Myung-Jin, Kim Jin-Ho, Choi Ji-Young, Kim Min-Seon, Jang Won-Cheoul, Lee Jung Jae, Eun Young Lee, Kwak Shang-June, Kim Ki Woong, Lee Seok Bum

Abstract excerpt

Sumoylation regulates transcription factor transactivation, protein-protein interactions, and appropriate subcellular localization of certain proteins. Previous studies have shown that sumoylation of amyloid precursor protein (APP) is associated with decreased levels of amyloid beta (Aβ) proteins, suggesting that sumoylation may play a role in the pathogenesis of Alzheimer's disease (AD). We investigated the...

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Source

Identifiers

PMID: 27084229
DOI: 10.1016/j.jns.2016.03.023

Genes

SUMO1
SUMO2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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