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Article

Genetic association between polymorphisms of Pen2 gene and late onset Alzheimer's disease in the North Chinese population.

Brain research - 13 Apr 2007

Jia Longfei, Ye Jing, L V Haiyan, Wang Weishan, Zhou Chunkui, Zhang Xiaojun, Xu Jiangtao, Wang Lingling, Jia Jianping

Abstract excerpt

UNLABELLED: Presenilin enhancer 2 (Pen2) is a subunit of the gamma-secretase complex which cleaves amyloid precursor protein (APP) to generate amyloid beta (Abeta). We performed a systematic screening of all Pen2 exons and introns using direct sequencing to assess its role in the risk of developi...

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Source

Identifiers

PMID: 17280645
DOI: 10.1016/j.brainres.2007.01.005

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17280645-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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