Article
Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population.
Psychiatry and clinical neurosciences - 1 Apr 2001
Kim H C, Kim D K, Choi I J, Kang K H, Yi S D, Park J, Park Y N
Abstract excerpt
The gene for human apolipoprotein E (APOE) is found on the long arm of chromosome 19 (19q13.2) and exists in three common allelic forms, epsilon2, epsilon3, and epsilon4. The APOE epsilon4 allele is overrepresented in Alzheimer's disease (AD) and is accepted as a genetic risk factor. Some studies reported a protective effect of the APOE epsilon2 allele for AD. However, there are some ethnic variations in the...
Topics
- Adult
- Aged
- Alzheimer Disease
- Apolipoproteins E
- Female
- Gene Frequency
- Genotype
- Humans
- Korea
- Male
- Middle Aged
- Polymerase Chain Reaction