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Article

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate.

Nucleic acids research - 19 May 2017

Harjes Stefan, Jameson Geoffrey B, Filichev Vyacheslav V, Edwards Patrick J B, Harjes Elena

Abstract excerpt

APOBEC3 proteins are double-edged swords. They deaminate cytosine to uracil in single-stranded DNA and provide protection, as part of our innate immune system, against viruses and retrotransposons, but they are also involved in cancer evolution and development of drug resistance. We report a solution-state model of APOBEC3A interaction with its single-stranded DNA substrate obtained with the 'method of small...

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Identifiers

PMID: 28369637
DOI: 10.1093/nar/gkx196
PMCID: PMC5435981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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