Article
The H-NS dimerization domain defines a new fold contributing to DNA recognition.
Nature structural biology - 1 Mar 2003
Bloch Vanessa, Yang Yinshan, Margeat Emmanuel, Chavanieu Alain, Augé Marie Thérèse, Robert Bruno, Arold Stefan, Rimsky Sylvie, Kochoyan Michel
Abstract excerpt
H-NS, a protein found in Gram-negative bacteria, is involved in structuring the bacterial chromosome and acts as a global regulator for the expression of a wide variety of genes. These functions are correlated with both its DNA-binding and oligomerization properties. We have identified the minimal dimerization domain of H-NS, a 46 amino acid-long N-terminal fragment, and determined its structure using...
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