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Article

DNA-binding of phenylalanyl-tRNA synthetase is accompanied by loop formation of the double-stranded DNA.

Journal of molecular biology - 19 Jan 2001

Dou X, Limmer S, Kreutzer R

Abstract excerpt

The phenylalanyl-tRNA synthetase (FRS) from Thermus thermophilus has previously been shown to bind DNA. We demonstrate that the "winged" helix-turn-helix motifs in the duplicate domains B5 are the relevant structural elements for this DNA-binding property. By altering particular amino acids in the "wing", the affinity of the FRS to DNA was significantly reduced. Based on experimental data, which indicate that the...

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Identifiers

PMID: 11152603
DOI: 10.1006/jmbi.2000.4312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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