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Article

Tnni3k modifies disease progression in murine models of cardiomyopathy.

PLoS genetics - 1 Sept 2009

Wheeler Ferrin C, Tang Hao, Marks Odessa A, Hadnott Tracy N, Chu Pei-Lun, Mao Lan, Rockman Howard A, Marchuk Douglas A

Abstract excerpt

The Calsequestrin (Csq) transgenic mouse model of cardiomyopathy exhibits wide variation in phenotypic progression dependent on genetic background. Seven heart failure modifier (Hrtfm) loci modify disease progression and outcome. Here we report Tnni3k (cardiac Troponin I-interacting kinase) as the gene underlying Hrtfm2. Strains with the more susceptible phenotype exhibit high transcript levels while less...

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Identifiers

PMID: 19763165
DOI: 10.1371/journal.pgen.1000647
PMCID: PMC2731170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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