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Article

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS genetics - 1 Jan 2012

Lodder Elisabeth M, Scicluna Brendon P, Milano Annalisa, Sun Albert Y, Tang Hao, Remme Carol Ann, Moerland Perry D, Tanck Michael W T, Pitt Geoffrey S, Marchuk Douglas A, Bezzina Connie R

Abstract excerpt

Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by prolongation of the PR interval on the surface electrocardiogram (ECG). Prolongation of the PR interval is also a strong predictor of atrial fibrillation, the most prevalent sustained cardiac arrhythmia. Despite the significant genetic component in PR duration...

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Identifiers

PMID: 23236294
DOI: 10.1371/journal.pgen.1003113
PMCID: PMC3516546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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