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Article

QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2005

Wheeler Ferrin C, Fernandez Liliana, Carlson Kerri M, Wolf Matthew J, Rockman Howard A, Marchuk Douglas A

Abstract excerpt

The progression from myocardial hypertrophy to heart failure is a complex process, involving genetic and environmental factors. Elucidating the genetic components contributing to heart failure has been difficult, largely because of the heterogeneity of human populations. We have employed a strategy to map genetic loci that modify the heart failure phenotype in a transgenic mouse model of cardiomyopathy caused by...

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PMID: 16075368
DOI: 10.1007/s00335-005-2468-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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