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Article

Mad1 destabilizes p53 by preventing PML from sequestering MDM2

4 Apr 2019

Abstract excerpt

Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. However, interphase roles of Mad1 that do not impact mitotic checkpoint function remain largely uncharacterized. Here we show that upregulation of Mad1, which is common in human breast cancer, prevents stress-induced stabilization of the tumor suppressor p53 in multiple cell types. Upregulated Mad1 localizes to...

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PMID: 30948704
DOI: 10.1038/s41467-019-09471-9

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