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Article

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

1 Oct 2000

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Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11017078
DOI: 10.1038/79930

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19PMID 11017078Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinomaSemantic proximity Read ↗

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19Semantic proximity Read ↗

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourSemantic proximity Read ↗

Regulation of Igf2 imprinting in development and disease.Semantic proximity Read ↗

A transcriptional insulator at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR)Semantic proximity Read ↗

Human IGF2 Gene Epigenetic and Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic BehaviorSemantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

Imprinting of Igf2 and H19 from a 130 kb YAC transgene.Semantic proximity Read ↗

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