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Article

Hypothesis-driven candidate gene association studies: practical design and analytical considerations.

American journal of epidemiology - 15 Oct 2009

Jorgensen Timothy J, Ruczinski Ingo, Kessing Bailey, Smith Michael W, Shugart Yin Yao, Alberg Anthony J

Abstract excerpt

Candidate gene association studies (CGAS) are a useful epidemiologic approach to drawing inferences about relations between genes and disease, especially when experimental data support the involvement of specific biochemical pathways. The value of CGAS is apparent when allele frequencies are low, effect sizes are small, or the study population is limited or unique. CGAS is also valuable for validating previous...

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Identifiers

PMID: 19762372
DOI: 10.1093/aje/kwp242
PMCID: PMC2765367

Genes

CGAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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