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Article

Genetic susceptibility: significance in risk assessment.

Toxicology letters - 28 Dec 1998

Portier C J, Bell D A

Abstract excerpt

Polymorphisms in metabolism and DNA-repair genes can increase the risks of cancer associated with exposure to chemical and physical agents in the environment. These types of gene-environment interactions may alter our view of dose-response patterns and how to characterize risk in an exposed population. Depending upon the action of the different forms of these genes, differing patterns of dose-response may be seen...

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PMID: 10022252
DOI: 10.1016/s0378-4274(98)00305-1

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