Article
Genetic susceptibility: significance in risk assessment.
Toxicology letters - 28 Dec 1998
Portier C J, Bell D A
Abstract excerpt
Polymorphisms in metabolism and DNA-repair genes can increase the risks of cancer associated with exposure to chemical and physical agents in the environment. These types of gene-environment interactions may alter our view of dose-response patterns and how to characterize risk in an exposed population. Depending upon the action of the different forms of these genes, differing patterns of dose-response may be seen...
Topics
- Arylamine N-Acetyltransferase
- Dose-Response Relationship, Drug
- Genetic Predisposition to Disease
- Humans
- Neoplasms
- Risk Assessment