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Article

Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1.

Protein science : a publication of the Protein Society - 1 Nov 2009

Gui Chunshan, Hagenbuch Bruno

Abstract excerpt

The liver-specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone-3-sulfate. In this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed mutagenesis. Functional...

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Identifiers

PMID: 19760661
DOI: 10.1002/pro.240
PMCID: PMC2788284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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