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Article

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.

The Journal of biological chemistry - 28 Oct 2011

Keller Thorsten, Egenberger Brigitte, Gorboulev Valentin, Bernhard Frank, Uzelac Zeljko, Gorbunov Dmitry, Wirth Christophe, Koppatz Stefan, Dötsch Volker, Hunte Carola, Sitte Harald H, Koepsell Hermann

Abstract excerpt

Polyspecific organic anion transporters (OATs) and organic cation transporters (OCTs) of the SLC22 transporter family play a pivotal role in absorption, distribution, and excretion of drugs. Polymorphisms in these transporters influence therapeutic effects. On the basis of functional characterizations, homology modeling, and mutagenesis, hypotheses for how OCTs bind and translocate structurally different cations...

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Identifiers

PMID: 21896487
DOI: 10.1074/jbc.M111.289330
PMCID: PMC3199529

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