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The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer

3 Mar 2011

Abstract excerpt

Organic anion transporting polypeptides (OATPs) are members of the SLCO gene superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies on the basis of their amino acid sequence similarities. OATPs are expressed in several epithelial tissues throughout the body and transport mainly amphipathic molecules with molecular weights of more than 300 kDa. Members of the OATP1 and OATP2...

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PMID: 21854228
DOI: 10.1146/annurev-pharmtox-010510-100556

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