Article
Genome-wide identification of human functional DNA using a neutral indel model.
PLoS computational biology - 1 Jan 2006
Lunter Gerton, Ponting Chris P, Hein Jotun
Abstract excerpt
It has become clear that a large proportion of functional DNA in the human genome does not code for protein. Identification of this non-coding functional sequence using comparative approaches is proving difficult and has previously been thought to require deep sequencing of multiple vertebrates. Here we introduce a new model and comparative method that, instead of nucleotide substitutions, uses the evolutionary...
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