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Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.

Molecular biology and evolution - 1 Sept 2009

Eyre-Walker Adam, Keightley Peter D

Abstract excerpt

The prevalence of adaptive evolution relative to genetic drift is a central problem in molecular evolution. Methods to estimate the fraction of adaptive nucleotide substitutions (alpha) have been developed, based on the McDonald-Kreitman test, that contrast polymorphism and divergence between selectively and neutrally evolving sites. However, these methods are expected to give downwardly biased estimates of alpha...

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PMID: 19535738
DOI: 10.1093/molbev/msp119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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