Article
Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project.
Nucleic acids research - 1 Sept 2011
Mu Xinmeng Jasmine, Lu Zhi John, Kong Yong, Lam Hugo Y K, Gerstein Mark B
Abstract excerpt
In the human genome, it has been estimated that considerably more sequence is under natural selection in non-coding regions [such as transcription-factor binding sites (TF-binding sites) and non-coding RNAs (ncRNAs)] compared to protein-coding ones. However, less attention has been paid to them. To study selective pressure on non-coding elements, we use next-generation sequencing data from the recently completed...
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