Article
Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2009
Yi Yu-Chiao, Chen Mu-Kuan, Chen Ling-Yun, Ho Esther Shih-Chu, Ying Tsung-Ho, Wang Po-Hui, Yang Shun-Fa
Abstract excerpt
BACKGROUND: Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities involved in tumorgenesis and mRNA expression of TIMP family members has been shown to be upregulated in numerous cancers and correlates with clinical outcomes. We investigated the association of TIMP-1 and TIMP-2 gene polymorphism with risk of endometrial...
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