Article
Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women.
Fertility and sterility - 1 Nov 2008
Kang Shan, Zhao Xi-Wa, Wang Na, Chen Shu-Cheng, Zhou Rong-Miao, Li Yan
Abstract excerpt
We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North...
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