Article
Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survival.
International journal of cancer - 15 Aug 2009
Peterson Neeraja B, Beeghly-Fadiel Alicia, Gao Yu-Tang, Long Jirong, Cai Qiuyin, Shu Xiao-ou, Zheng Wei
Abstract excerpt
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases which are involved in normal cellular processes and also in cancer development and progression. The purpose of this study was to evaluate polymorphisms in the TIMP-2 and TIMP-3 genes for their associations with breast cancer susceptibility and survival. Using data from the Shanghai Breast Cancer Study, 19 SNPs...
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