Article
Association of interferon-gamma gene polymorphisms in Taiwanese children with biliary atresia.
Journal of clinical immunology - 1 Jan 2010
Lee Hung-Chang, Chang Tzu-Yang, Yeung Chun-Yan, Chan Wai-Tao, Jiang Chuen-Bin, Chen Wei-Fang, Chan Hui-Wen, Liu Hsin-Fu, Lin Marie, Lee Yann-Jinn
Abstract excerpt
BACKGROUND: Biliary atresia (BA) is a devastating neonatal hepatobiliary disease characterized by bile duct inflammation and fibrosis. The pathogenesis remains unclear, but immunologically mediated injury to bile ducts following an infectious insult is likely to play a critical role. Interferon-gamma (IFN-gamma) is a key cytokine that affects immune-mediated inflammatory responses. OBJECTIVE: This study aims to...
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