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Genetically modified mouse models for the study of nonalcoholic fatty liver disease

1 Jan 2012

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (1) fatty liver (hepatic steatosis); (2) steatosis with inflammation and necrosis; to (3) cirrhosis. The animal models to study NAFLD/nonalcoholic steatohepatitis (NASH) are extremely useful, as there are still many events to be elucidated in the...

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PMID: 22468076
DOI: 10.3748/wjg.v18.i11.1141

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