Article
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells.
Cell - 7 Sept 1990
Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien Y H, Weissman I L
Abstract excerpt
Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- Bone Marrow
- CD3 Complex
- CD8 Antigens
- Cell Differentiation
- Cell Division
- Colony-Forming Units Assay
- Fetus