Article
Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver.
Blood - 1 Dec 2000
Hsu H C, Ema H, Osawa M, Nakamura Y, Suda T, Nakauchi H
Abstract excerpt
Tie-2 receptor tyrosine kinase expressed in endothelial and hematopoietic cells is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. This article addressed whether Tie-2 is expressed on fetal liver hematopoietic stem cells (HSCs) at day 14 of gestation. With the use of anti-Tie-2 monoclonal antibody, its expression was detected in approximately 7% of an HSC...
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