Article
Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver.
Blood - 1 Dec 2000
Hsu H C, Ema H, Osawa M, Nakamura Y, Suda T, Nakauchi H
Abstract excerpt
Tie-2 receptor tyrosine kinase expressed in endothelial and hematopoietic cells is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. This article addressed whether Tie-2 is expressed on fetal liver hematopoietic stem cells (HSCs) at day 14 of gestation. With the use of anti-Tie-2 monoclonal antibody, its expression was detected in approximately 7% of an HSC...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Ly
- Bone Marrow Cells
- Cell Lineage
- Female
- Fetus
- Hematopoiesis
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Liver
- Male
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Phenotype
- Proto-Oncogene Proteins c-kit