Article
Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.
PloS one - 15 Sept 2009
Karami Sara, Brennan Paul, Rosenberg Philip S, Navratilova Marie, Mates Dana, Zaridze David, Janout Vladimir, Kollarova Helena, Bencko Vladimir, Matveev Vsevolod, Szeszenia-Dabrowska Neonila, Holcatova Ivana, Yeager Meredith, Chanock Stephen, Menashe Idan, Rothman Nathaniel, Chow Wong-Ho, Boffetta Paolo, Moore Lee E
Abstract excerpt
In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology. RCC cases (N = 777)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.