Article
Genetic variants predisposing to increased risk of kidney stone disease
2024-06-11
Abstract excerpt
Kidney stones (KS) are common, heritable, and associated with mineral metabolism abnormalities. We used Mendelian randomization and colocalization to identify variants predicted to increase KS risk via increased serum calcium or decreased serum phosphate (odds ratios for genomic regions=4.30-13.83 per 1 standard deviation alteration) that account for 11-19% of KS due to reduced calcium-sensing receptor (CaSR)-sign...
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Identifiers and source
- Literature Corpus work
- 8ca9f77a-8c92-508a-953f-596c1d281789
- DOI
- 10.1101/2024.06.07.24308490